APOL1 renal risk variants exacerbate podocyte injury by increasing inflammatory stress

BACKGROUND: Apolipoprotein L1, APOL1, is a trypanosome lytic factor present in human and certain other primates. APOL1 gene variants, present in individuals of recent sub-Saharan African descent, increase risk for glomerular disease and associate with the disease progression, but the molecular mecha...

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Detalles Bibliográficos
Publicado en:BMC Nephrol
Main Authors: Wakashin, Hidefumi, Heymann, Jurgen, Roshanravan, Hila, Daneshpajouhnejad, Parnaz, Rosenberg, Avi, Shin, Myung Kyun, Hoek, Maarten, Kopp, Jeffrey B.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2020
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7450955/
https://ncbi.nlm.nih.gov/pubmed/32854642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12882-020-01995-3
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