Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization

Pulmonary fibrosis (PF) is a major public health problem with limited therapeutic options. There is a clear need to identify novel mediators of PF to develop effective therapeutics. Here we show that an ER protein disulfide isomerase, thioredoxin domain containing 5 (TXNDC5), is highly upregulated i...

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Published in:Nat Commun
Main Authors: Lee, Tzu-Han, Yeh, Chih-Fan, Lee, Ying-Tung, Shih, Ying-Chun, Chen, Yen-Ting, Hung, Chen-Ting, You, Ming-Yi, Wu, Pei-Chen, Shentu, Tzu-Pin, Huang, Ru-Ting, Lin, Yu-Shan, Wu, Yueh-Feng, Lin, Sung-Jan, Lu, Frank-Leigh, Tsao, Po-Nien, Lin, Tzu-Hung, Lo, Shen-Chuan, Tseng, Yi-Shuan, Wu, Wan-Lin, Chen, Chiung-Nien, Wu, Chau-Chung, Lin, Shuei-Liong, Sperling, Anne I., Guzy, Robert D., Fang, Yun, Yang, Kai-Chien
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449970/
https://ncbi.nlm.nih.gov/pubmed/32848143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18047-x
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