Endoplasmic Reticulum Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast Activation

RATIONALE: Cardiac fibrosis plays a critical role in the pathogenesis of heart failure (HF). Excessive accumulation of extracellular matrix (ECM) resulting from cardiac fibrosis impairs cardiac contractile function and increases arrhythmogenicity. Current treatment options for cardiac fibrosis, howe...

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Publicado en:Circ Res
Autores principales: Shih, Ying-Chun, Chen, Chao-Ling, Zhang, Yan, Mellor, Rebecca L., Kanter, Evelyn M., Fang, Yun, Wang, Hua-Chi, Hung, Chen-Ting, Nong, Jing-Yi, Chen, Hui-Ju, Lee, Tzu-Han, Tseng, Yi-Shuan, Chen, Chiung-Nien, Wu, Chau-Chung, Lin, Shuei-Liong, Yamada, Kathryn A., Nerbonne, Jeanne M., Yang, Kai-Chien
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899016/
https://ncbi.nlm.nih.gov/pubmed/29535165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.312130
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