Endoplasmic Reticulum Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast Activation

RATIONALE: Cardiac fibrosis plays a critical role in the pathogenesis of heart failure (HF). Excessive accumulation of extracellular matrix (ECM) resulting from cardiac fibrosis impairs cardiac contractile function and increases arrhythmogenicity. Current treatment options for cardiac fibrosis, howe...

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Detalhes bibliográficos
Publicado no:Circ Res
Main Authors: Shih, Ying-Chun, Chen, Chao-Ling, Zhang, Yan, Mellor, Rebecca L., Kanter, Evelyn M., Fang, Yun, Wang, Hua-Chi, Hung, Chen-Ting, Nong, Jing-Yi, Chen, Hui-Ju, Lee, Tzu-Han, Tseng, Yi-Shuan, Chen, Chiung-Nien, Wu, Chau-Chung, Lin, Shuei-Liong, Yamada, Kathryn A., Nerbonne, Jeanne M., Yang, Kai-Chien
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899016/
https://ncbi.nlm.nih.gov/pubmed/29535165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.312130
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