Endoplasmic Reticulum Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast Activation

RATIONALE: Cardiac fibrosis plays a critical role in the pathogenesis of heart failure (HF). Excessive accumulation of extracellular matrix (ECM) resulting from cardiac fibrosis impairs cardiac contractile function and increases arrhythmogenicity. Current treatment options for cardiac fibrosis, howe...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Circ Res
Main Authors: Shih, Ying-Chun, Chen, Chao-Ling, Zhang, Yan, Mellor, Rebecca L., Kanter, Evelyn M., Fang, Yun, Wang, Hua-Chi, Hung, Chen-Ting, Nong, Jing-Yi, Chen, Hui-Ju, Lee, Tzu-Han, Tseng, Yi-Shuan, Chen, Chiung-Nien, Wu, Chau-Chung, Lin, Shuei-Liong, Yamada, Kathryn A., Nerbonne, Jeanne M., Yang, Kai-Chien
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899016/
https://ncbi.nlm.nih.gov/pubmed/29535165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.312130
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki