Assessment of DNA damage by 53PB1 and pKu70 detection in peripheral blood lymphocytes by immunofluorescence and high-resolution transmission electron microscopy

PURPOSE: 53BP1 foci detection in peripheral blood lymphocytes (PBLs) by immunofluorescence microscopy (IFM) is a sensitive and quantifiable DNA double-strand break (DSB) marker. In addition, high-resolution transmission electron microscopy (TEM) with immunogold labeling of 53BP1 and DSB-bound phosph...

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Bibliografische gegevens
Gepubliceerd in:Strahlenther Onkol
Hoofdauteurs: Lorat, Yvonne, Fleckenstein, Jochen, Görlinger, Patric, Rübe, Christian, Rübe, Claudia E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer Berlin Heidelberg 2020
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449954/
https://ncbi.nlm.nih.gov/pubmed/32006067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00066-020-01576-1
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