Transient receptor potential vanilloid-4 contributes to stretch-induced hypercontractility and time-dependent dysfunction in the aged heart

AIMS: Cardiovascular disease remains the greatest cause of mortality in Americans over 65. The stretch-activated transient receptor potential vanilloid-4 (TRPV4) ion channel is expressed in cardiomyocytes of the aged heart. This investigation tests the hypothesis that TRPV4 alters Ca(2+) handling an...

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Pubblicato in:Cardiovasc Res
Autori principali: Veteto, Adam B, Peana, Deborah, Lambert, Michelle D, McDonald, Kerry S, Domeier, Timothy L
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Review Series from the Naples 2019 Joint Meeting of the ESC Working Groups on Myocardial Function and Cellular Biology of the Heart
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449559/
https://ncbi.nlm.nih.gov/pubmed/31693106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvz287
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