Elevated Ca(2+) transients and increased myofibrillar power generation cause cardiac hypercontractility in a model of Noonan syndrome with multiple lentigines

Noonan syndrome with multiple lentigines (NSML) is primarily caused by mutations in the nonreceptor protein tyrosine phosphatase SHP2 and associated with congenital heart disease in the form of pulmonary valve stenosis and hypertrophic cardiomyopathy (HCM). Our goal was to elucidate the cellular mec...

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Bibliographic Details
Published in:Am J Physiol Heart Circ Physiol
Main Authors: Clay, Sarah A., Domeier, Timothy L., Hanft, Laurin M., McDonald, Kerry S., Krenz, Maike
Format: Artigo
Language:Inglês
Published: American Physiological Society 2015
Subjects:
Muscle Mechanics and Ventricular Function
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551123/
https://ncbi.nlm.nih.gov/pubmed/25724491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00501.2014
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