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Elevated Ca(2+) transients and increased myofibrillar power generation cause cardiac hypercontractility in a model of Noonan syndrome with multiple lentigines
Noonan syndrome with multiple lentigines (NSML) is primarily caused by mutations in the nonreceptor protein tyrosine phosphatase SHP2 and associated with congenital heart disease in the form of pulmonary valve stenosis and hypertrophic cardiomyopathy (HCM). Our goal was to elucidate the cellular mec...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Am J Physiol Heart Circ Physiol |
|---|---|
| Prif Awduron: | , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
American Physiological Society
2015
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4551123/ https://ncbi.nlm.nih.gov/pubmed/25724491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00501.2014 |
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