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Spectrophotometric determination of α-hydroxytropolone pK(a) values: A structure-acidity relationship study

α-Hydroxytropolones (αHTs) have a wealth of biological activity owing to their ability to serve as metalbinding fragments for many therapeutically valuable dinuclear metalloenzymes. They also have the potential to exist in as many as 4 protonation states under aqueous acidic or basic conditions. The...

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Publicat a:Tetrahedron Lett
Autors principals: Stasiak, John P., Grigoryan, Alexandre, Murelli, Ryan P.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449261/
https://ncbi.nlm.nih.gov/pubmed/32855576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2019.05.034
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