ERK regulates HIF-1α-mediated platinum resistance by directly targeting PHD2 in ovarian cancer

PURPOSE: Up to 80% of ovarian cancer patients develop platinum-resistance over time of platinum-based chemotherapy. Increased HIF-1α level is an important mechanism governing platinum-resistance in platinum-resistant ovarian cancer (PROC). However, the mechanism regulating HIF-1α stability in PROC r...

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Enregistré dans:
Détails bibliographiques
Publié dans:Clin Cancer Res
Auteurs principaux: Li, Zhuqing, Zhou, Wei, Zhang, Yi, Sun, Wei, Yung, Mingo MH, Sun, Jing, Li, Jing, Chen, Chi-Wei, Li, Zongzhu, Meng, Yunxiao, Chai, Jie, Zhou, Yuan, Liu, Stephanie S, Cheung, Annie NY, Ngan, Hextan YS, Chan, David W., Zheng, Wei, Zhu, Wenge
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449248/
https://ncbi.nlm.nih.gov/pubmed/31285371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-4145
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