Candida glabrata Transcription Factor Rpn4 Mediates Fluconazole Resistance through Regulation of Ergosterol Biosynthesis and Plasma Membrane Permeability

The ability to acquire azole resistance is an emblematic trait of the fungal pathogen Candida glabrata. Understanding the molecular basis of azole resistance in this pathogen is crucial for designing more suitable therapeutic strategies. This study shows that the C. glabrata transcription factor (TF...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Pais, Pedro, Califórnia, Raquel, Galocha, Mónica, Viana, Romeu, Ola, Mihaela, Cavalheiro, Mafalda, Takahashi-Nakaguchi, Azusa, Chibana, Hiroji, Butler, Geraldine, Teixeira, Miguel C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449212/
https://ncbi.nlm.nih.gov/pubmed/32571817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00554-20
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