Candida glabrata Transcription Factor Rpn4 Mediates Fluconazole Resistance through Regulation of Ergosterol Biosynthesis and Plasma Membrane Permeability

The ability to acquire azole resistance is an emblematic trait of the fungal pathogen Candida glabrata. Understanding the molecular basis of azole resistance in this pathogen is crucial for designing more suitable therapeutic strategies. This study shows that the C. glabrata transcription factor (TF...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Pais, Pedro, Califórnia, Raquel, Galocha, Mónica, Viana, Romeu, Ola, Mihaela, Cavalheiro, Mafalda, Takahashi-Nakaguchi, Azusa, Chibana, Hiroji, Butler, Geraldine, Teixeira, Miguel C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2020
Soggetti:
Mechanisms of Resistance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449212/
https://ncbi.nlm.nih.gov/pubmed/32571817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00554-20
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