Prolonged Exposure to β-Lactam Antibiotics Reestablishes Susceptibility of Daptomycin-Nonsusceptible Staphylococcus aureus to Daptomycin

Daptomycin-nonsusceptible (DAP-NS) Staphylococcus aureus often exhibits gain-in-function mutations in the mprF gene (involved in positive surface charge maintenance). Standard β-lactams, although relatively inactive against methicillin-resistant S. aureus (MRSA), may prevent the emergence of mprF mu...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Jenson, Rachel E., Baines, Sarah L., Howden, Benjamin P., Mishra, Nagendra N., Farah, Sabrina, Lew, Cassandra, Berti, Andrew D., Shukla, Sanjay K., Bayer, Arnold S., Rose, Warren E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2020
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449200/
https://ncbi.nlm.nih.gov/pubmed/32601160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00890-20
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