Safety, Pharmacokinetics, and Activity of High-Dose Ivermectin and Chloroquine against the Liver Stage of Plasmodium cynomolgi Infection in Rhesus Macaques

Previously, ivermectin (1 to 10 mg/kg of body weight) was shown to inhibit the liver-stage development of Plasmodium berghei in orally dosed mice. Here, ivermectin showed inhibition of the in vitro development of Plasmodium cynomolgi schizonts (50% inhibitory concentration [IC(50)], 10.42 μM) and hy...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Vanachayangkul, Pattaraporn, Im-erbsin, Rawiwan, Tungtaeng, Anchalee, Kodchakorn, Chanikarn, Roth, Alison, Adams, John, Chaisatit, Chaiyaporn, Saingam, Piyaporn, Sciotti, Richard J., Reichard, Gregory A., Nolan, Christina K., Pybus, Brandon S., Black, Chad C., Lugo-Roman, Luis A., Wegner, Matthew D., Smith, Philip L., Wojnarski, Mariusz, Vesely, Brian A., Kobylinski, Kevin C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449176/
https://ncbi.nlm.nih.gov/pubmed/32660993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00741-20
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