ATI-2173, a Novel Liver-Targeted Non-Chain-Terminating Nucleotide for Hepatitis B Virus Cure Regimens

ATI-2173 is a novel liver-targeted molecule designed to deliver the 5′-monophosphate of clevudine for the treatment of chronic hepatitis B infection. Unlike other nucleos(t)ides, the active clevudine-5′-triphosphate is a noncompetitive, non-chain-terminating inhibitor of hepatitis B virus (HBV) poly...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Squires, Katherine E., Mayers, Douglas L., Bluemling, Gregory R., Kolykhalov, Alexander A., Guthrie, David B., Reddy, Prabhakar, Mitchell, Debbie G., Saindane, Manohar T., Sticher, Zachary M., Edpuganti, Vindhya, De La Rosa, Abel
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2020
Sujets:
Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449170/
https://ncbi.nlm.nih.gov/pubmed/32540975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00836-20
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