ATI-2173, a Novel Liver-Targeted Non-Chain-Terminating Nucleotide for Hepatitis B Virus Cure Regimens

ATI-2173 is a novel liver-targeted molecule designed to deliver the 5′-monophosphate of clevudine for the treatment of chronic hepatitis B infection. Unlike other nucleos(t)ides, the active clevudine-5′-triphosphate is a noncompetitive, non-chain-terminating inhibitor of hepatitis B virus (HBV) poly...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Squires, Katherine E., Mayers, Douglas L., Bluemling, Gregory R., Kolykhalov, Alexander A., Guthrie, David B., Reddy, Prabhakar, Mitchell, Debbie G., Saindane, Manohar T., Sticher, Zachary M., Edpuganti, Vindhya, De La Rosa, Abel
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2020
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449170/
https://ncbi.nlm.nih.gov/pubmed/32540975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00836-20
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