Particulate multivalent presentation of the receptor binding domain induces protective immune responses against MERS-CoV

Middle East respiratory syndrome coronavirus (MERS-CoV) is a WHO priority pathogen for which vaccines are urgently needed. Using an immune-focusing approach, we created self-assembling particles multivalently displaying critical regions of the MERS-CoV spike protein ─fusion peptide, heptad repeat 2,...

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發表在:Emerg Microbes Infect
Main Authors: Okba, Nisreen M. A., Widjaja, Ivy, van Dieren, Brenda, Aebischer, Andrea, van Amerongen, Geert, de Waal, Leon, Stittelaar, Koert J., Schipper, Debby, Martina, Byron, van den Brand, Judith M. A., Beer, Martin, Bosch, Berend-Jan, Haagmans, Bart L.
格式: Artigo
語言:Inglês
出版: Taylor & Francis 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7448924/
https://ncbi.nlm.nih.gov/pubmed/32471334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/22221751.2020.1760735
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