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PSCAN: Spatial scan tests guided by protein structures improve complex disease gene discovery and signal variant detection
Germline disease-causing variants are generally more spatially clustered in protein 3-dimensional structures than benign variants. Motivated by this tendency, we develop a fast and powerful protein-structure-based scan (PSCAN) approach for evaluating gene-level associations with complex disease and...
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| Publicado no: | Genome Biol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7448521/ https://ncbi.nlm.nih.gov/pubmed/32847609 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-02121-0 |
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