PSCAN: Spatial scan tests guided by protein structures improve complex disease gene discovery and signal variant detection

Germline disease-causing variants are generally more spatially clustered in protein 3-dimensional structures than benign variants. Motivated by this tendency, we develop a fast and powerful protein-structure-based scan (PSCAN) approach for evaluating gene-level associations with complex disease and...

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Vydáno v:Genome Biol
Hlavní autoři: Tang, Zheng-Zheng, Sliwoski, Gregory R., Chen, Guanhua, Jin, Bowen, Bush, William S., Li, Bingshan, Capra, John A.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
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Method
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7448521/
https://ncbi.nlm.nih.gov/pubmed/32847609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-02121-0
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