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Unstructured regions of large enzymatic complexes control the availability of metabolites with signaling functions

ABSTRACT: Metabolites produced via traditional biochemical processes affect intracellular communication, inflammation, and malignancy. Unexpectedly, acetyl-CoA, α-ketoglutarate and palmitic acid, which are chemical species of reactions catalyzed by highly abundant, gigantic enzymatic complexes, dubb...

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Veröffentlicht in:Cell Commun Signal
Hauptverfasser: Skalidis, Ioannis, Tüting, Christian, Kastritis, Panagiotis L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7448341/
https://ncbi.nlm.nih.gov/pubmed/32843078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00631-9
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