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Simultaneous Determination of Six Uncaria Alkaloids in Mouse Blood by UPLC–MS/MS and Its Application in Pharmacokinetics and Bioavailability

A specific ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method has been developed for the simultaneous determination of six Uncaria alkaloids in mouse blood with midazolam as the internal standard (IS). Only 20 μL blood was needed for sample preparation, and the prote...

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Bibliographische Detailangaben
Veröffentlicht in:Biomed Res Int
Hauptverfasser: Chen, Lianguo, Ma, Jianshe, Wang, Xianqin, Zhang, Meiling
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7448256/
https://ncbi.nlm.nih.gov/pubmed/32879877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/1030269
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