Simultaneous Determination of Six Uncaria Alkaloids in Mouse Blood by UPLC–MS/MS and Its Application in Pharmacokinetics and Bioavailability

A specific ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method has been developed for the simultaneous determination of six Uncaria alkaloids in mouse blood with midazolam as the internal standard (IS). Only 20 μL blood was needed for sample preparation, and the prote...

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Bibliographic Details
Published in:Biomed Res Int
Main Authors: Chen, Lianguo, Ma, Jianshe, Wang, Xianqin, Zhang, Meiling
Format: Artigo
Language:Inglês
Published: Hindawi 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7448256/
https://ncbi.nlm.nih.gov/pubmed/32879877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/1030269
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