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Simultaneous Determination of Six Uncaria Alkaloids in Mouse Blood by UPLC–MS/MS and Its Application in Pharmacokinetics and Bioavailability

A specific ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method has been developed for the simultaneous determination of six Uncaria alkaloids in mouse blood with midazolam as the internal standard (IS). Only 20 μL blood was needed for sample preparation, and the prote...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Chen, Lianguo, Ma, Jianshe, Wang, Xianqin, Zhang, Meiling
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7448256/
https://ncbi.nlm.nih.gov/pubmed/32879877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/1030269
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