Simultaneous Determination of Six Uncaria Alkaloids in Mouse Blood by UPLC–MS/MS and Its Application in Pharmacokinetics and Bioavailability

A specific ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method has been developed for the simultaneous determination of six Uncaria alkaloids in mouse blood with midazolam as the internal standard (IS). Only 20 μL blood was needed for sample preparation, and the prote...

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Udgivet i:Biomed Res Int
Main Authors: Chen, Lianguo, Ma, Jianshe, Wang, Xianqin, Zhang, Meiling
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7448256/
https://ncbi.nlm.nih.gov/pubmed/32879877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/1030269
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