Use of ratiometrically designed nanocarrier targeting CDK4/6 and autophagy pathways for effective pancreatic cancer treatment

Aberrant cell cycle machinery and loss of the CDKN2A tumor suppressor locus make CDK4/6 a potential target in pancreatic ductal adenocarcinoma (PDAC). However, a vast majority of PDAC cases do not harbor a durable response to monotherapy of CDK4/6 inhibitor. Utilizing remote loading to co-encapsulat...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Ji, Ying, Liu, Xiangsheng, Li, Juan, Xie, Xiaodong, Huang, Max, Jiang, Jinhong, Liao, Yu-Pei, Donahue, Timothy, Meng, Huan
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7447818/
https://ncbi.nlm.nih.gov/pubmed/32843618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17996-7
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