Heterologous expression of high-activity cytochrome P450 in mammalian cells

The evaluation of Cytochrome P450 (CYP) enzymatic activity is essential to estimate drug pharmacokinetics. Numerous CYP allelic variants have been identified; the functional characterisation of these variants is required for their application in precision medicine. Results from heterologous expressi...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Kumondai, Masaki, Hishinuma, Eiji, Gutiérrez Rico, Evelyn Marie, Ito, Akio, Nakanishi, Yuya, Saigusa, Daisuke, Hirasawa, Noriyasu, Hiratsuka, Masahiro
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7447777/
https://ncbi.nlm.nih.gov/pubmed/32843676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71035-5
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