Functional Assessment of 12 Rare Allelic CYP2C9 Variants Identified in a Population of 4773 Japanese Individuals

Cytochrome P450 2C9 (CYP2C9) is an important drug-metabolizing enzyme that contributes to the metabolism of approximately 15% of clinically used drugs, including warfarin, which is known for its narrow therapeutic window. Interindividual differences in CYP2C9 enzymatic activity caused by CYP2C9 gene...

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Gepubliceerd in:J Pers Med
Hoofdauteurs: Kumondai, Masaki, Ito, Akio, Gutiérrez Rico, Evelyn Marie, Hishinuma, Eiji, Ueda, Akiko, Saito, Sakae, Nakayoshi, Tomoki, Oda, Akifumi, Tadaka, Shu, Kinoshita, Kengo, Maekawa, Masamitsu, Mano, Nariyasu, Hirasawa, Noriyasu, Hiratsuka, Masahiro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7912942/
https://ncbi.nlm.nih.gov/pubmed/33540768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jpm11020094
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