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Regulation of epithelial-mesenchymal transition and organoid morphogenesis by a novel TGFβ-TCF7L2 isoform-specific signaling pathway

Alternative splicing contributes to diversification of gene function, yet consequences of splicing on functions of specific gene products is poorly understood. The major transcription factor TCF7L2 undergoes alternative splicing but the biological significance of TCF7L2 isoforms has remained largely...

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發表在:Cell Death Dis
Main Authors: Karve, Kunal, Netherton, Stuart, Deng, Lili, Bonni, Azad, Bonni, Shirin
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7447769/
https://ncbi.nlm.nih.gov/pubmed/32843642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02905-z
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