Characterization of FLT3-ITD(mut) acute myeloid leukemia: molecular profiling of leukemic precursor cells

Acute myeloid leukemia (AML) with FLT3-ITD mutations (FLT3-ITD(mut)) remains a therapeutic challenge, with a still high relapse rate, despite targeted treatment with tyrosine kinase inhibitors. In this disease, the CD34/CD123/CD25/CD99+ leukemic precursor cells (LPCs) phenotype predicts for FLT3-ITD...

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Publicat a:Blood Cancer J
Autors principals: Travaglini, Serena, Angelini, Daniela Francesca, Alfonso, Valentina, Guerrera, Gisella, Lavorgna, Serena, Divona, Mariadomenica, Nardozza, Anna Maria, Consalvo, Maria Irno, Fabiani, Emiliano, De Bardi, Marco, Neri, Benedetta, Forghieri, Fabio, Marchesi, Francesco, Paterno, Giovangiacinto, Cerretti, Raffaella, Barragan, Eva, Fiori, Valentina, Dominici, Sabrina, Del Principe, Maria Ilaria, Venditti, Adriano, Battistini, Luca, Arcese, William, Lo-Coco, Francesco, Voso, Maria Teresa, Ottone, Tiziana
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7447750/
https://ncbi.nlm.nih.gov/pubmed/32843624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41408-020-00352-9
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