Human carnosinase 1 overexpression aggravates diabetes and renal impairment in BTBR(Ob/Ob) mice

OBJECTIVE: To assess the influence of serum carnosinase (CN1) on the course of diabetic kidney disease (DKD). METHODS: hCN1 transgenic (TG) mice were generated in a BTBR(Ob/Ob) genetic background to allow the spontaneous development of DKD in the presence of serum carnosinase. The influence of serum...

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Pubblicato in:J Mol Med (Berl)
Autori principali: Qiu, Jiedong, Albrecht, Thomas, Zhang, Shiqi, Hauske, Sibylle J., Rodriguez-Niño, Angelica, Zhang, Xinmiao, Nosan, Darya, Pastene, Diego O., Sticht, Carsten, Delatorre, Carolina, van Goor, Harry, Porubsky, Stefan, Krämer, Bernhard K., Yard, Benito A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2020
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7447680/
https://ncbi.nlm.nih.gov/pubmed/32803273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-020-01957-0
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