Lithium reduces blood glucose levels, but aggravates albuminuria in BTBR-ob/ob mice

Glycogen synthase kinase 3 (GSK3) plays an important role in the development of diabetes mellitus and renal injury. GSK3 inhibition increases glucose uptake in insulin-insensitive muscle and adipose tissue, while it reduces albuminuria and glomerulosclerosis in acute kidney injury. The effect of chr...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: de Groot, Theun, Damen, Lars, Kosse, Leanne, Alsady, Mohammad, Doty, Rosalinda, Baumgarten, Ruben, Sheehan, Susan, van der Vlag, Johan, Korstanje, Ron, Deen, Peter M. T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5731748/
https://ncbi.nlm.nih.gov/pubmed/29244860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0189485
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