Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis

Increased extracellular Ca(2+) concentrations ([Ca(2+)](ex)) trigger activation of the NLRP3 inflammasome in monocytes through calcium-sensing receptor (CaSR). To prevent extraosseous calcification in vivo, the serum protein fetuin-A stabilizes calcium and phosphate into 70-100 nm-sized colloidal ca...

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Publicado no:Nat Commun
Main Authors: Jäger, Elisabeth, Murthy, Supriya, Schmidt, Caroline, Hahn, Magdalena, Strobel, Sarah, Peters, Anna, Stäubert, Claudia, Sungur, Pelin, Venus, Tom, Geisler, Mandy, Radusheva, Veselina, Raps, Stefanie, Rothe, Kathrin, Scholz, Roger, Jung, Sebastian, Wagner, Sylke, Pierer, Matthias, Seifert, Olga, Chang, Wenhan, Estrela-Lopis, Irina, Raulien, Nora, Krohn, Knut, Sträter, Norbert, Hoeppener, Stephanie, Schöneberg, Torsten, Rossol, Manuela, Wagner, Ulf
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7447633/
https://ncbi.nlm.nih.gov/pubmed/32843625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17749-6
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