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Toll-Like Receptor 4 Is Involved in Inflammatory and Joint Destructive Pathways in Collagen-Induced Arthritis in DBA1J Mice

In rheumatoid arthritis, a significant proportion of cytokine and chemokine synthesis is attributed to innate immune mechanisms. TLR4 is a prominent innate receptor since several endogenous ligands known to activate the innate immune system bind to it and may thereby promote joint inflammation. We g...

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Bibliographic Details
Main Authors: Pierer, Matthias, Wagner, Ulf, Rossol, Manuela, Ibrahim, Saleh
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157404/
https://ncbi.nlm.nih.gov/pubmed/21858160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023539
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