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Extracellular Ca(2+) is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors
Activation of the NLRP3 inflammasome enables monocytes and macrophages to release high levels of interleukin-1β during inflammatory responses. Concentrations of extracellular calcium can increase at sites of infection, inflammation or cell activation. Here we show that increased extracellular calciu...
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| Autori principali: | , , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Pub. Group
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3535422/ https://ncbi.nlm.nih.gov/pubmed/23271661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2339 |
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