Extracellular Ca(2+) is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors

Activation of the NLRP3 inflammasome enables monocytes and macrophages to release high levels of interleukin-1β during inflammatory responses. Concentrations of extracellular calcium can increase at sites of infection, inflammation or cell activation. Here we show that increased extracellular calciu...

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Autori principali: Rossol, Manuela, Pierer, Matthias, Raulien, Nora, Quandt, Dagmar, Meusch, Undine, Rothe, Kathrin, Schubert, Kristin, Schöneberg, Torsten, Schaefer, Michael, Krügel, Ute, Smajilovic, Sanela, Bräuner-Osborne, Hans, Baerwald, Christoph, Wagner, Ulf
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535422/
https://ncbi.nlm.nih.gov/pubmed/23271661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2339
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