Impaired glymphatic function and clearance of tau in an Alzheimer’s disease model

The glymphatic system, that is aquaporin 4 (AQP4) facilitated exchange of CSF with interstitial fluid (ISF), may provide a clearance pathway for protein species such as amyloid-β and tau, which accumulate in the brain in Alzheimer’s disease. Further, tau protein transference via the extracellular sp...

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Enregistré dans:
Détails bibliographiques
Publié dans:Brain
Auteurs principaux: Harrison, Ian F, Ismail, Ozama, Machhada, Asif, Colgan, Niall, Ohene, Yolanda, Nahavandi, Payam, Ahmed, Zeshan, Fisher, Alice, Meftah, Soraya, Murray, Tracey K, Ottersen, Ole P, Nagelhus, Erlend A, O’Neill, Michael J, Wells, Jack A, Lythgoe, Mark F
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2020
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7447521/
https://ncbi.nlm.nih.gov/pubmed/32705145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awaa179
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