Impaired glymphatic function and clearance of tau in an Alzheimer’s disease model

The glymphatic system, that is aquaporin 4 (AQP4) facilitated exchange of CSF with interstitial fluid (ISF), may provide a clearance pathway for protein species such as amyloid-β and tau, which accumulate in the brain in Alzheimer’s disease. Further, tau protein transference via the extracellular sp...

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Bibliografische gegevens
Gepubliceerd in:Brain
Hoofdauteurs: Harrison, Ian F, Ismail, Ozama, Machhada, Asif, Colgan, Niall, Ohene, Yolanda, Nahavandi, Payam, Ahmed, Zeshan, Fisher, Alice, Meftah, Soraya, Murray, Tracey K, Ottersen, Ole P, Nagelhus, Erlend A, O’Neill, Michael J, Wells, Jack A, Lythgoe, Mark F
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2020
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Original Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7447521/
https://ncbi.nlm.nih.gov/pubmed/32705145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awaa179
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