Deletion of the von Hippel-Lindau Gene in Hemangioblasts Causes Hemangioblastoma-like Lesions in Murine Retina

von Hippel-Lindau (VHL) disease is an autosomal-dominant tumor predisposition syndrome characterized by the development of highly vascularized tumors and cysts. LOH of the VHL gene results in aberrant upregulation of hypoxia-inducible factors (HIF) and has been associated with tumor formation. Heman...

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Udgivet i:	Cancer Res
Main Authors:	Wang, Herui, Shepard, Matthew J., Zhang, Chao, Dong, Lijin, Walker, Dyvon, Guedez, Liliana, Park, Stanley, Wang, Yujuan, Chen, Shida, Pang, Ying, Zhang, Qi, Gao, Chun, Wong, Wai T., Wiley, Henry, Pacak, Karel, Chew, Emily Y., Zhuang, Zhengping, Chan, Chi-Chao
Format:	Artigo
Sprog:	Inglês
Udgivet:	2018
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7446935/ https://ncbi.nlm.nih.gov/pubmed/29301791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1718
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Deletion of the von Hippel-Lindau Gene in Hemangioblasts Causes Hemangioblastoma-like Lesions in Murine Retina

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