Deletion of the von Hippel-Lindau Gene in Hemangioblasts Causes Hemangioblastoma-like Lesions in Murine Retina

von Hippel-Lindau (VHL) disease is an autosomal-dominant tumor predisposition syndrome characterized by the development of highly vascularized tumors and cysts. LOH of the VHL gene results in aberrant upregulation of hypoxia-inducible factors (HIF) and has been associated with tumor formation. Heman...

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Pubblicato in:Cancer Res
Autori principali: Wang, Herui, Shepard, Matthew J., Zhang, Chao, Dong, Lijin, Walker, Dyvon, Guedez, Liliana, Park, Stanley, Wang, Yujuan, Chen, Shida, Pang, Ying, Zhang, Qi, Gao, Chun, Wong, Wai T., Wiley, Henry, Pacak, Karel, Chew, Emily Y., Zhuang, Zhengping, Chan, Chi-Chao
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446935/
https://ncbi.nlm.nih.gov/pubmed/29301791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1718
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