Alpha-crystallin mutations alter lens metabolites in mouse models of human cataracts

Cataracts are a major cause of blindness worldwide and commonly occur in individuals over 70 years old. Cataracts can also appear earlier in life due to genetic mutations. The lens proteins, αA- and αB-crystallins, are chaperone proteins that have important roles maintaining protein solubility to pr...

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Bibliographic Details
Published in:PLoS One
Main Authors: Frankfater, Cheryl, Bozeman, Stephanie L., Hsu, Fong-Fu, Andley, Usha P.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446835/
https://ncbi.nlm.nih.gov/pubmed/32833997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0238081
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