Exploring Predictors of Response to Dacomitinib in EGFR-Amplified Recurrent Glioblastoma

PURPOSE: Despite the high frequency of EGFR genetic alterations in glioblastoma (GBM), EGFR-targeted therapies have not had success in this disease. To improve the likelihood of efficacy, we targeted adult patients with recurrent GBM enriched for EGFR gene amplification, which occurs in approximatel...

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Detalhes bibliográficos
Publicado no:JCO Precis Oncol
Main Authors: Chi, Andrew S., Cahill, Daniel P., Reardon, David A., Wen, Patrick Y., Mikkelsen, Tom, Peereboom, David M., Wong, Eric T., Gerstner, Elizabeth R., Dietrich, Jorg, Plotkin, Scott R., Norden, Andrew D., Lee, Eudocia Q., Nayak, Lakshmi, Tanaka, Shota, Wakimoto, Hiroaki, Lelic, Nina, Koerner, Mara V., Klofas, Lindsay K., Bertalan, Mia S., Arrillaga-Romany, Isabel C., Betensky, Rebecca A., Curry, William T., Borger, Darrel R., Balaj, Leonora, Kitchen, Robert R., Chakrabortty, Sudipto K., Valentino, Michael D., Skog, Johan, Breakefield, Xandra O., Iafrate, A. John, Batchelor, Tracy T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2020
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446412/
https://ncbi.nlm.nih.gov/pubmed/32923886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.19.00295
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