Exploring Predictors of Response to Dacomitinib in EGFR-Amplified Recurrent Glioblastoma

PURPOSE: Despite the high frequency of EGFR genetic alterations in glioblastoma (GBM), EGFR-targeted therapies have not had success in this disease. To improve the likelihood of efficacy, we targeted adult patients with recurrent GBM enriched for EGFR gene amplification, which occurs in approximatel...

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Bibliographic Details
Published in:JCO Precis Oncol
Main Authors: Chi, Andrew S., Cahill, Daniel P., Reardon, David A., Wen, Patrick Y., Mikkelsen, Tom, Peereboom, David M., Wong, Eric T., Gerstner, Elizabeth R., Dietrich, Jorg, Plotkin, Scott R., Norden, Andrew D., Lee, Eudocia Q., Nayak, Lakshmi, Tanaka, Shota, Wakimoto, Hiroaki, Lelic, Nina, Koerner, Mara V., Klofas, Lindsay K., Bertalan, Mia S., Arrillaga-Romany, Isabel C., Betensky, Rebecca A., Curry, William T., Borger, Darrel R., Balaj, Leonora, Kitchen, Robert R., Chakrabortty, Sudipto K., Valentino, Michael D., Skog, Johan, Breakefield, Xandra O., Iafrate, A. John, Batchelor, Tracy T.
Format: Artigo
Language:Inglês
Published: American Society of Clinical Oncology 2020
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Original Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446412/
https://ncbi.nlm.nih.gov/pubmed/32923886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.19.00295
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