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T cell exhaustion and a failure in antigen presentation drive resistance to the graft-versus-leukemia effect
In hematopoietic cell transplants, alloreactive T cells mediate the graft-versus-leukemia (GVL) effect. However, leukemia relapse accounts for nearly half of deaths. Understanding GVL failure requires a system in which GVL-inducing T cells can be tracked. We used such a model wherein GVL is exclusiv...
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| Опубликовано в: : | Nat Commun |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7445289/ https://ncbi.nlm.nih.gov/pubmed/32839441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17991-y |
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