Differential requirements for myeloid leukemia IFN-γ conditioning determine graft-versus-leukemia resistance and sensitivity

The graft-versus-leukemia (GVL) effect in allogeneic hematopoietic stem cell transplantation (alloSCT) is potent against chronic phase chronic myelogenous leukemia (CP-CML), but blast crisis CML (BC-CML) and acute myeloid leukemias (AML) are GVL resistant. To understand GVL resistance, we studied GV...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Matte-Martone, Catherine, Liu, Jinling, Zhou, Meng, Chikina, Maria, Green, Douglas R., Harty, John T., Shlomchik, Warren D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490746/
https://ncbi.nlm.nih.gov/pubmed/28604385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85736
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