Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo

Irisin, a skeletal-muscle secreted myokine, facilitates muscle-bone crosstalk and skeletal remodeling in part by its action on osteoblasts and osteocytes. In this study, we investigated whether irisin directly regulates osteoclasts. In vitro, irisin (2–10 ng/mL) increased osteoclast differentiation...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Estell, Eben G, Le, Phuong T, Vegting, Yosta, Kim, Hyeonwoo, Wrann, Christiane, Bouxsein, Mary L, Nagano, Kenichi, Baron, Roland, Spiegelman, Bruce M, Rosen, Clifford J
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2020
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7444909/
https://ncbi.nlm.nih.gov/pubmed/32780016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58172
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