The Role of Zfp467 in Mediating the Pro-osteogenic and Anti-adipogenic Effects on Bone and Bone Marrow Niche

Conditional deletion of the PTH receptor (Pth1r) in mesenchymal progenitors reduces osteoblast differentiation and bone mass while enhancing adipogenesis and bone marrow adipose tissue. Mechanistically, PTH suppresses the expression of Zfp467, a pro-adipogenic zinc finger transcription factor. Conse...

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Detalhes bibliográficos
Publicado no:Bone
Main Authors: Le, Phuong T., Liu, Hanghang, Alabdulaaly, Lama, Vegting, Yosta, Calle, Isabella L, Gori, Francesca, Lanske, Beate, Baron, Roland, Rosen, Clifford J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8175945/
https://ncbi.nlm.nih.gov/pubmed/33359894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2020.115832
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