Therapeutic Targeting of SDHB-Mutated Pheochromocytoma/Paraganglioma with Pharmacologic Ascorbic Acid

PURPOSE: Pheochromocytomas and paragangliomas (PCPG) are usually benign neuroendocrine tumors. However, PCPGs with mutations in the succinate dehydrogenase B subunit (SDHB) have a poor prognosis and frequently develop metastatic lesions. SDHB-mutated PCPGs exhibit dysregulation in oxygen metabolic p...

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Détails bibliographiques
Publié dans:Clin Cancer Res
Auteurs principaux: Liu, Yang, Pang, Ying, Zhu, Boqun, Uher, Ondrej, Caisova, Veronika, Huynh, Thanh-Truc, Taieb, David, Vanova, Katerina Hadrava, Ghayee, Hans Kumar, Neuzil, Jiri, Levine, Mark, Yang, Chunzhang, Pacak, Karel
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443979/
https://ncbi.nlm.nih.gov/pubmed/32152203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-2335
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