Targeting NRF2-Governed Glutathione Synthesis for SDHB-Mutated Pheochromocytoma and Paraganglioma

Succinate dehydrogenase subunit B (SDHB) deficiency frequently occurs in cluster I pheochromocytomas and paragangliomas (PCPGs). SDHB-mutated PCPGs are characterized by alterations in the electron transport chain, metabolic reprogramming of the tricarboxylic cycle, and elevated levels of reactive ox...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Liu, Yang, Pang, Ying, Caisova, Veronika, Ding, Jianyi, Yu, Di, Zhou, Yiqiang, Huynh, Thanh-Truc, Ghayee, Hans, Pacak, Karel, Yang, Chunzhang
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072390/
https://ncbi.nlm.nih.gov/pubmed/31979226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12020280
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