Targeting NAD(+)/PARP DNA Repair Pathway as a Novel Therapeutic Approach to SDHB-Mutated Cluster I Pheochromocytoma and Paraganglioma

PURPOSE: Cluster I pheochromocytomas and paragangliomas (PCPGs) tend to develop malignant transformation, tumor recurrence, and multiplicity. Transcriptomic profiling suggests that cluster I PCPGs and other related tumors exhibit distinctive changes in the tricarboxylic acid (TCA) cycle, the hypoxia...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Pang, Ying, Lu, Yanxin, Caisova, Veronika, Liu, Yang, Bullova, Petra, Huynh, Thanh-Truc, Zhou, Yiqiang, Yu, Di, Frysak, Zdenek, Hartmann, Igor, Taïeb, David, Pacak, Karel, Yang, Chunzhang
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446242/
https://ncbi.nlm.nih.gov/pubmed/29636359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-3406
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