Parkinson’s disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EM

Posttranslational modifications (PTMs) of α-synuclein (α-syn), e.g., phosphorylation, play an important role in modulating α-syn pathology in Parkinson’s disease (PD) and α-synucleinopathies. Accumulation of phosphorylated α-syn fibrils in Lewy bodies and Lewy neurites is the histological hallmark o...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Zhao, Kun, Lim, Yeh-Jun, Liu, Zhenying, Long, Houfang, Sun, Yunpeng, Hu, Jin-Jian, Zhao, Chunyu, Tao, Youqi, Zhang, Xing, Li, Dan, Li, Yan-Mei, Liu, Cong
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443891/
https://ncbi.nlm.nih.gov/pubmed/32737160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1922741117
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