A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission

Arboviruses maintain high mutation rates due to lack of proofreading ability of their viral polymerases, in some cases facilitating adaptive evolution and emergence. Here we show that, just before its 2013 spread to the Americas, Zika virus (ZIKV) underwent an envelope protein V473M substitution (E-...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Shan, Chao, Xia, Hongjie, Haller, Sherry L., Azar, Sasha R., Liu, Yang, Liu, Jianying, Muruato, Antonio E., Chen, Rubing, Rossi, Shannan L., Wakamiya, Maki, Vasilakis, Nikos, Pei, Rongjuan, Fontes-Garfias, Camila R., Singh, Sanjay Kumar, Xie, Xuping, Weaver, Scott C., Shi, Pei-Yong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2020
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443865/
https://ncbi.nlm.nih.gov/pubmed/32747564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2005722117
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