A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission

Arboviruses maintain high mutation rates due to lack of proofreading ability of their viral polymerases, in some cases facilitating adaptive evolution and emergence. Here we show that, just before its 2013 spread to the Americas, Zika virus (ZIKV) underwent an envelope protein V473M substitution (E-...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Shan, Chao, Xia, Hongjie, Haller, Sherry L., Azar, Sasha R., Liu, Yang, Liu, Jianying, Muruato, Antonio E., Chen, Rubing, Rossi, Shannan L., Wakamiya, Maki, Vasilakis, Nikos, Pei, Rongjuan, Fontes-Garfias, Camila R., Singh, Sanjay Kumar, Xie, Xuping, Weaver, Scott C., Shi, Pei-Yong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2020
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443865/
https://ncbi.nlm.nih.gov/pubmed/32747564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2005722117
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