Hairpin RNA-induced conformational change of a eukaryotic-specific lysyl-tRNA synthetase extension and role of adjacent anticodon-binding domain

Human lysyl-tRNA synthetase (hLysRS) is essential for aminoacylation of tRNA(Lys). Higher eukaryotic LysRSs possess an N-terminal extension (Nterm) previously shown to facilitate high-affinity tRNA binding and aminoacylation. This eukaryote-specific appended domain also plays a critical role in hLys...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Liu, Sheng, Refaei, Maryanne, Liu, Shuohui, Decker, Aaron, Hinerman, Jennifer M., Herr, Andrew B., Howell, Mike, Musier-Forsyth, Karin, Tsang, Pearl
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443506/
https://ncbi.nlm.nih.gov/pubmed/32611767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013852
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